Synthesis and characterization of 4-amino-4H-1,2,4-triazole derivatives: Anticonvulsant activity

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

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Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

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Synthesis, Characterization and Anticonvulsant Activity of Some Novel 4, 5-Disubstituted-1, 2, 4-Triazole Derivatives

Article history: Received on: 07/02/2017 Accepted on: 21/03/2017 Available online: 30/07/2017 The current therapy of epilepsy is associated with a number of side effects including sedation and hypnosis. Newer improved molecules are needed with lesser side effects and with improved physical properties. In view of these facts, a series of novel 4, 5-disubstituted-1,2,4-triazoles (6a-o) were synth...

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synthesis and anticonvulsant activity evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4h-1,2,4 -triazole

a series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4h-1,2,4-triazole was synthesized. the anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (mes) test and rotarod tests with intraperitoneally injected mice. among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4h-1,2,4-triazole (5f) was the most active one and also had...

متن کامل

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4-(hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

متن کامل

Synthesis and characterization of 4-amino-4H-1,2,4-triazole derivatives: Anticonvulsant activity

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Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

Synthesis, Characterization and Anticonvulsant Activity of Some Novel 4, 5-Disubstituted-1, 2, 4-Triazole Derivatives

synthesis and anticonvulsant activity evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4h-1,2,4 -triazole

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4-(hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

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